Comparison of structure-activity relations of corazonin using two different bioassay systems |
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Authors: | Tanaka Y Ishibashi J Tanaka S |
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Institution: | Laboratory of Insect Growth Regulation, National Institute of Agrobiological Science, Tsukuba, Ibaraki 305-8634, Japan. yoshiaki@affrc.go.jp |
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Abstract: | The structure-activity relations of His(7)]-corazonin were studied using two different bioassay systems; i.e. inhibitory effect on spinning rate in the silkworm, Bombyx mori, and darkening response in albino nymphs of the migratory locust, Locusta migratoria. Deletion of the N-terminus, shortening of the peptide and single amino acid substitutions reduced activity in a similar manner except for the minimum effective dose in the two insects. The results also revealed that the residues at position 1, 3 and 5 were particularly important for biological activity. Despite the different physiological affects, the two insect species exhibited similar structure-activity relationships, suggesting that they might have similar receptor systems. |
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