An octakis-intercalating molecule |
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| Authors: | Murr M M Harting M T Guelev V Ren J Chaires J B Iverson B L |
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| Institution: | Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA. |
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| Abstract: | Herein we report the synthesis and characterization of a polyintercalator with eight potential intercalating l,4,5,8-naphthalenetetracarboxylic diimide (NDI) units linked in a head-to-tail arrangement via a peptide linker. UV spectroscopy and viscometry measurements indicated the molecule binds to double-stranded DNA with all eight NDI units intercalated simultaneously. Competition dialysis and DNAse 1 footprinting studies revealed a preference for GC-rich regions of DNA, and circular dichroism studies revealed significant distortion of B-form DNA upon binding. Our so-called "octamer" represents, to the best of our knowledge, the first intercalator that binds as an octakis-intercalator, capable of spanning at least 16 base pairs of DNA. |
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