On a Model Mechanism for the Spatial Patterning of Teeth Primordia in the Alligator |
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| Authors: | P.M. Kulesa G.C. Cruywagen S.R. Lubkin P.K. Main J. Sneyd M.W.J. Ferguson J.D. Murray |
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| Affiliation: | aDivision of Biology, Beckman Institute (139-74), California Institute of Technology, Pasadena, CA, 91125, U.S.A.;bSea Fisheries Research Institute, Rogge Bay, 8012 Capetown, South Africa;cDepartment of Applied Mathematics, University of Washington, Seattle, WA 98195-2420, U.S.A.;dCentre for Mathematical Biology, Mathematical Institute, 24-29 St Giles', Oxford, OX1 3LB, U.K.;eDepartment of Mathematics, University of Canterbury, Christchurch, NZ;fSchool of Biological Sciences, The University of Manchester, 3.239 Stopford Building, Oxford Road, Manchester, M13 9PT, U.K. |
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| Abstract: | We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role in the developmental patterning of the tooth initiation process. Based on biological data we develop a reaction-diffusion mechanism, which crucially includes domain growth. The model can reproduce the spatial pattern development of the first seven teeth primordia in the lower half jaw ofA. mississippiensis. The results for the precise spatio-temporal sequence compare well with detailed developmental experiments. |
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