Proteins binding to the 5'-flanking regulatory elements of the human β-globin gene~1 |
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作者姓名: | CHEN ZHIGANG YADI CHEN JIHUA XU RUOLAN QIANShanghai Institute of Cell Biology Academia Sinica Shanghai 200031 China |
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作者单位: | CHEN ZHIGANG,YADI CHEN,JIHUA XU,RUOLAN QIANShanghai Institute of Cell Biology,Academia Sinica,Shanghai 200031,China |
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基金项目: | gramts from shanghai Joint Laboratory of Life sciences,Academia Sinica,and the National National sciences Foundation, |
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摘 要: | The binding of nuclear proteins prepared from mouse erythroid tissue in different developmental stages to the 5'-flanking regulatory elements of human globin gene, two negative control regions(NCR1, -610 to -490 bp; NCR2,-338 to -233bp), was identified. Two stage specific protein factors corresponding to embryonic and fetal stages were found to be capable of binding to NCR2. These data provided evidence that the cis acting elements of the 5'-flanking region might be involved in the developmental control of globin gene and NCR2 might be responsible in part for the silence of globin gene in the embryonic and fetal stages.
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关 键 词: | human β-globin gene negative control region stage specific factor. |
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