Autoradiographic studies with 3H 1,25 (OH)2 vitamin D3 and 3H 25 (OH) vitamin D3 in rat parathyroid glands |
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| Authors: | W. E. Stumpf M. Sar F. A. Reid S. Huang R. Narbaitz H. F. DeLuca |
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| Affiliation: | (1) Department of Anatomy, University of North Carolina, Chapel Hill, North Carolina, USA;(2) Department of Anatomy, University of Ottawa, Ottawa, Ontario, Canada;(3) Department of Biochemistry, University of Wisconsin, Wisconsin, Madison, USA;(4) Department of Anatomy, University of North Carolina, 111 Swing Building, 27514 Chapel Hill, NC, USA |
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| Abstract: | Summary After injection of radiolabeled 1,25 (OH)2 vitamin D3, nuclear concentration of radioactivity is observed in parenchymal cells of the parathyroid gland in pregnant, adult male, and 10-day male neonatal rats. In competition studies with unlabeled 1,25 (OH)2 vitamin D3, but not with 25 (OH) vitamin D3, nuclear uptake is prevented. Experiments with 3H 25 (OH) vitamin D3, in contrast to 3H 1,25 (OH)2 vitamin D3, do not show nuclear concentration in cells of the parathyroid. The results of the autoradiographic studies suggest the presence of receptors for a direct effect of 1,25 (OH)2 vitamin D3 on the parathyroid gland for modulation of parathyroid hormone secretion. |
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| Keywords: | 1,25(OH)2 Vitamin D3 Receptors Parathyroid glands Autoradiography |
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