Treatment with poly I.C. enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats |
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| Authors: | A Koizumi R L Walford T Imamura |
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| Affiliation: | 1. Division of Toxicology and Physiology, University of California, Riverside, CA 92521 USA;1. CNRS, LaBRI, Université de Bordeaux, Bordeaux, France;2. University of Leeds, United Kingdom;3. Univ Rennes, F-35000 Rennes, France;1. Department of Addiction, ASL CN2, Corso Coppino 46, 12051 Alba (CN), Italy;2. Department of Mental Health, ASL CN1, Via Torino 70/B, 12037 Saluzzo (CN), Italy;1. Brain Institute, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil;2. Neurological Surgery Department, University of California, San Francisco 94158, USA;3. Cardiovascular Research Institute, National University of Singapore, Singapore 117599, Singapore;4. Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore 169857, Singapore;5. School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore;6. School of Engineering, Temasek Polytechnic, Singapore 529757, Singapore;7. Stanford Institute for Stem Cell Biology & Regenerative Medicine, Department of Developmental Biology, Stanford-UC Berkeley Siebel Stem Cell Institute, Stanford University School of Medicine, Stanford, CA 94305, USA;9. Department of Microbiology, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore |
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| Abstract: | Treatment of mice and rats with polyriboinosinic acid-polyribocytidylic acid (poly I.C., 5 mg/kg i.p.), a potent interferon inducer, decreased hepatic cytochrome P-450 system content and activities without influencing P-450-independent xenobiotic metabolizing enzymes. Treatment with poly I.C. decreased the content of P-450 by 28% in mice (P less than 0.05) and 30% in rats (P less than 0.05) but did not alter the activity of cytochrome c reductase. With treatment of poly I.C., the activity of XO increased 87% in mice (P less than 0.01) and 30% in rats (P less than 0.01). Lipid peroxidation was enhanced by 82% in mice (P less than 0.01) and 95% in rats (P less than 0.05). These results raise the possibility that a part of the depression of P-450 system content and activities by poly I.C. might be caused by enhanced lipid peroxidation associated with increased activity of XO. |
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