Geographical distribution of genetic polymorphism of the pathogen Histoplasma capsulatum isolated from infected bats,captured in a central zone of Mexico |
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| Authors: | Maria Lucia Taylor Catalina B Chávez-Tapia Alberto Rojas-Martínez Maria del Rocio Reyes-Montes Mirian Bobadilla del Valle Gerardo Zúñiga |
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| Institution: | 1. Laboratorio de Inmunología de Hongos, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, México DF, 04510, Mexico;2. Laboratorio de Zoología, FES-Iztacala, Universidad Nacional Autónoma de México (UNAM), México DF, 54090, Mexico;3. Escuela de Biología, Universidad Simón Bolívar, México DF, 03920, Mexico;4. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, México DF, 14000, Mexico;5. Departamento de Zoología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México DF, 11340, Mexico;1. Department of Internal Medicine, Infectious Diseases Division, Washington University, School of Medicine Campus Box 8051, 660 S. Euclid Ave., St. Louis Missouri 63110-1093 USA. Tel.: +1 40 61 35 18; fax: +1 40 61 34 19;2. Laboratorio de Inmunología de Hongos, Depto. de Microbiología y Parasitología, Facultad de Medicina, UNAM Cd. Universitaria 04510 México, D.F. Tel.:/fax: +52 555 56-23-24-62;3. Lille-2 University Hospital Center and Ecology of Parasitism, Institute Pasteur of Lille 1, rue du Prof-Calmette - BP245 59019 Lille cedex (France) Tel.: +33 3 20 87 71 55; fax: +33 3 20 87 72 24 |
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| Abstract: | Fourteen Histoplasma capsulatum isolates recovered from infected bats captured in Mexican caves and two human H. capsulatum reference strains were analyzed using random amplification of polymorphic DNA PCR-based and partial DNA sequences of four genes. Cluster analysis of random amplification of polymorphic DNA-patterns revealed differences for two H. capsulatum isolates of one migratory bat Tadarida brasiliensis. Three groups were identified by distance and maximum-parsimony analyses of arf, H-anti, ole, and tub1 H. capsulatum genes. Group I included most isolates from infected bats and one clinical strain from central Mexico; group II included the two isolates from T. brasiliensis; the human G-217B reference strain from USA formed an independent group III. Isolates from group II showed diversity in relation to groups I and III, suggesting a different H. capsulatum population. |
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