TEP/IRM hybride en neuro-imagerie |
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| Authors: | V Garibotto C Tabouret-Viaud O Rager S Vulliemoz B Delattre S Haller M Wissmeyer M Seeck KO Lovblad H Zaidi G Gold O Ratib D Zekry MI Vargas |
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| Institution: | 1. Service de médecine nucléaire et imagerie moléculaire, département d’imagerie et des sciences de l’information médicale, hôpitaux universitaires de Genève, rue Gabrielle-Perret-Gentil 4, 1211 Genève, Suisse;2. Unité d’EEG et d’exploration de l’épilepsie, département de neurosciences cliniques, hôpitaux universitaires de Genève, Suisse;3. Philips healthcare AG, Zurich, Suisse;4. Département de médecine interne, de réhabilitation et de gériatrie, hôpitaux universitaires de Genève, Suisse;1. Service de médecine nucléaire, hôpital Lariboisière, 2, rue Ambroise Paré, 75010 Paris, France;2. UFR/SM, service de biophysique et médecine nucléaire, CHU de Cocody, Bp V166, Abidjan, Côte d’Ivoire;3. Direction de la coordination de la radioprotection, faculté de médecine Saint-Pères, 75006 Paris, France;1. Service de médecine nucléaire, hôpital Ibn Sina, CHIS, rue Lamfadel Cherkaoui, BP 6527, Rabat, Maroc;2. Université MedV, Suissi, Rabat, Maroc;1. Service de médecine nucléaire, hôpitaux universitaires de Genève, rue Gabrielle-Pierret-Gentil 4, 1205 Genève, Suisse;2. Service de médecine nucléaire, hôpital de La Tour, Genève, Suisse;3. Service de radiologie, hôpital de La Tour, Genève, Suisse;4. Service de médecine interne, hôpital de La Tour, Genève, Suisse;5. Service de chirurgie, hôpital de La Tour, Genève, Suisse;1. Service de médecine nucléaire, centre hospitalier universitaire Vaudois, rue du Bugnon-46, 1011 Lausanne, Suisse;2. Service de radiodiagnostic et radiologie interventionnelle, centre hospitalier universitaire Vaudois, Lausanne, Suisse;3. Pneumologie, immuno-allergologie et médecine interne, hôpital Pourtalès, Neuchâtel, Suisse |
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| Abstract: | The hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) is a newly available imaging modality combining the molecular and metabolic PET information with the morphological and functional data provided by MRI. Integrated PET/MRI tomographs were conceived in analogy to the current PET/Computed Tomography (PET/CT) technology, with specific properties linked to the intrinsic differences of MRI and CT imaging. In the field of neuro-imaging, in particular, MRI provides a larger panel of information, as compared with CT, and is already systematically fused and used as a support for PET images for diagnostic and research purposes. We summarize here our current experience with the first integrated PET/MRI tomograph installed in Switzerland, concerning specifically three clinical applications: brain tumors characterization, the diagnosis of neurodegenerative dementias and the presurgical evaluation of pharmaco-resistant epilepsy. With this sequential tomograph, we could combine the full range of diagnostic MR sequences (including diffusion tensor imaging, tractography, spectroscopy, functional MR) with PET imaging of brain glucose metabolism (by 18F-Fluorodeoxyglucose–FDG) and of amino acid transport (by 18F-Fluoroethyltyrosine–FET). We also summarize the main results obtained in neuro-imaging by the different groups working with these new hybrid tomographs. These data show that PET/MRI, acquired in a single imaging session, may represent the modality of choice for neuro-imaging. |
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| Keywords: | PET/MRI Neuro-imaging Epilepsy Oncology Neurodegenerative disorders Dementias |
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