Immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in isolated pancreatic acini of guinea pigs and rats |
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| Authors: | Broccardo Maria Ciotti M Teresa Linari Giorgio Agostini Simona Petrella Carla Amadoro Giusy Severini Cinzia Improta Giovanna |
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| Institution: | Department of Human Physiology and Pharmacology, V. Erspamer, University La Sapienza, Rome, Italy. |
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| Abstract: | In this study, we investigated the immunocytochemical distribution of NK-1 and NK-3 tachykinin receptors in guinea pig and rat isolated pancreatic acini. In dispersed acinar cells from guinea pig, immunofluorescence staining detected similar densities of NK-1 and NK-3 receptors; conversely, rat acinar cells expressed NK-1 receptors more strongly than NK-3 receptors. In line with previous functional studies, these immunocytochemical findings suggest that guinea pig NK-1 and NK-3 receptors and rat NK-1 receptors alone play a direct stimulatory role in the basal pancreatic acinar amylase release. |
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