A decreased effect of organic phosphates on hemoglobin S at low concentrations. |
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Authors: | Y Ueda R M Bookchin R L Nagel |
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Institution: | Department of Physiology and Biochemistry, Royal Veterinary College, London NW1 OTU, U.K. |
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Abstract: | Livers from fasted male rats were perfused with blood containing 30% carboxyhemoglobin. Chylomicron remnants (labelled with 3H] cholesterol and 14C] oleate), prepared in functionally hepatectomized rats, were added to the perfusate. Carboxyhemoglobin decreased hepatic uptake of remnant cholesterol and increased the amount of lipoprotein flushed out of the liver at the end of perfusion. Transfer of triacylglycerol fatty acids to phospholipid and formation of d>1.006 lipoproteins was diminished. Ketogenesis was increased and lipoprotein triacylglycerol secretion decreased. The data indicate an inhibition of hepatic remnant catabolism by carboxyhemoglobin and are discussed with reference to the possible role of smoking in atherosclerosis. |
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Keywords: | COHb carboxyhemoglobin Hb hemoglobin TGFA triacylglycerol fatty acids VLDL very low density lipoproteins (d<1 006) |
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