Surface coats and secretory trafficking in African trypanosomes |
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Authors: | Bangs J D |
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Affiliation: | Department of Medical Microbiology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA. bangs@macc.wisc.edu |
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Abstract: | Recent advances in transfection technology have been exploited to address fundamental questions relating to secretory trafficking in African trypanosomes. Targeted gene disruptions and ectopic expression of the major stage-specific surface proteins have provided unexpected insights into both the function and assembly of the essential parasite surface coats. A growing list of novel secretory cargo molecules, as well as advances in the characterization of trypanosomal secretory machinery, provide a unique model system for the study of eukaryotic secretory processes. |
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