| 急性白血病患者血清、脑脊液趋化因子SDF-1测定及意义 |
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| 引用本文： | 章大谦,吴广胜.急性白血病患者血清、脑脊液趋化因子SDF-1测定及意义[J].现代生物医学进展,2010,10(3). |
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| 作者姓名： | 章大谦 吴广胜 |
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| 作者单位： | 石河子大学医学院第一附属医院血液科,新疆石河子,832002 |
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| 摘 要： | 目的:为了探讨基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)及其受体CXCR4在急性白血病血清及脑脊液中的变化及临床意义。方法:用酶联免疫吸附双抗体夹心法(ELISA)测定45例急性白血病患者的血清及40例急性白血病患者的脑脊液中SDF-1,并分别与正常对照组比较。结果:1.ALL患者组、AML患者组及正常对照组血清的SDF-1水平分别为4255.46±2685.83,2405.10±905.24,2338.24±671.21(pg/ml),其中ALL组患者明显高于AML组及正常组,且差异具有统计学意义(P<0.05)。CNSL患者组及非CNSL患者组SDF-1血清水平分别为3696.30±432.49,3136.62±2157.64(pg/ml),组间无显著差别。2.ALL患者组、AML患者组及正常对照组脑脊液SDF-1水平分别为4576.15±1547.96,3097.20±1408.45,1983.61±857.98(pg/ml),其中急性白血病组高于正常对照组,差异具有统计学意义(P<0.05),ALL组高于AML组,差异也具有统计学意义(P<0.05)...
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| 关 键 词： | 急性白血病 SDF-1 脑脊液 |
Determination of CSF chemokine SDF-1 and the serum of patients with acute leukemia |
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| ZHANG Da-qian,WU Guang-sheng.Determination of CSF chemokine SDF-1 and the serum of patients with acute leukemia[J].Progress in Modern Biomedicine,2010,10(3). |
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| Authors: | ZHANG Da-qian WU Guang-sheng |
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| Institution: | ZHANG Da-qian,WU Guang-sheng. (Department of Hematology,First Affiliated Hospital of Medical College,Shihezi University,Shihezi 832002,China) |
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| Abstract: | |
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| Keywords: | Acute leukemia Stromal cell derived factor-1 Cerebrospinal fluid |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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