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A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics
Authors:Yu-Ru Su  Chongzhi Di  Stephanie Bien  Licai Huang  Xinyuan Dong  Goncalo Abecasis  Sonja Berndt  Stephane Bezieau  Hermann Brenner  Bette Caan  Graham Casey  Jenny Chang-Claude  Stephen Chanock  Sai Chen  Charles Connolly  Keith Curtis  Jane Figueiredo  Manish Gala  Li Hsu
Affiliation:1. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;2. Department of Biostatistics, University of Washington, Seattle, WA 98195, USA;3. Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA;4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA;5. Service de Génétique Médicale Centre Hospitalier Universitaire (CHU) Nantes, Nantes 44093, France;6. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany;7. Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA 94612, USA;8. Public Health Sciences Division, University of Virginia, Charlottesville, VA 22908, USA;9. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69009, Germany;10. Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA;11. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA;12. Department of Surgery, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada;13. Melborne School of Population Health, The University of Melborne, Carlton, VIC 3010, Australia;14. Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA;15. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA;16. Genome Sciences, University of Washington, Seattle, WA 98195, USA;17. Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA;18. Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA;19. Division of Hematology, Faculty of Medicine, The University of Ottawa, Ottawa, ON K1Y 4E9, USA;20. Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98109, USA;21. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Abstract:
Keywords:mixed-effects score test  functional annotation  expression quantitative trait locus  data-adaptive weight  variance component test  set-based association  genome-wide association study
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