An analysis of developmental timing in Dictyostelium discoideum |
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Authors: | Barbara Varnum Lee Mitchell David R. Soll |
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Affiliation: | Department of Zoology, University of Iowa, Iowa City, Iowa 52242 USA |
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Abstract: | A new method has been developed to assess the minimum complexity and relationships of those pathways (developmental timers) which time the consecutive stages of a developing system (Soll, 1983). This method has been applied to the morphogenetic program of Dictyostelium discoideum and has resulted in (1) a minimum estimate of the number of components comprising the timers for the first seven stages of morphogenesis, (2) a characterization of the temperature sensitivities of these components including demonstration of a reversible timer component, (3) detailed temporal definition of a number of transition points between rate-limiting components including a major branch point for the onset of several independent timer components coincident with the onset of aggregation, and (4) a temporal model for the relationships between the timers of the seven consecutive morphogenetic stages, including several examples of parallel timers. |
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Keywords: | To whom all correspondence should be addressed: Department of Zoology University of Iowa Iowa City Iowa 52242. |
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