DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules |
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| Authors: | Bruno M Tesson Rainer Breitling Ritsert C Jansen |
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| Affiliation: | 1.Groningen Bioinformatics Center,University of Groningen,the Netherlands;2.Institute of Molecular,Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow,Glasgow,UK;3.Department of Genetics,University Medical Center Groningen,Groningen,the Netherlands |
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| Abstract: | Background Large microarray datasets have enabled gene regulation to be studied through coexpression analysis. While numerous methods have been developed for identifying differentially expressed genes between two conditions, the field of differential coexpression analysis is still relatively new. More specifically, there is so far no sensitive and untargeted method to identify gene modules (also known as gene sets or clusters) that are differentially coexpressed between two conditions. Here, sensitive and untargeted means that the method should be able to construct de novo modules by grouping genes based on shared, but subtle, differential correlation patterns. |
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