The human leukocyte antigen class I genes in nasopharyngeal carcinoma risk |
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Authors: | Elham Hassen Ghandri Nahla Noureddine Bouaouina Lotfi Chouchane |
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Institution: | (1) Faculty of Medicine of Monastir, Molecular Immuno-oncology Laboratory, Monastir University, 5019 Monastir, Tunisia;(2) Departement of Cancerology and Radiotherapy, CHU Farhat Hached, Sousse, Tunisia;(3) Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar |
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Abstract: | Nasopharyngeal carcinoma (NPC) is a virally associated cancer which is highly prevalent in Southeast Asia and North Africa.
Several linkage analysis studies suggested the association of susceptibility HLA (Human Leukocyte Antigen) alleles and haplotypes
with NPC development. The HLA system is very polymorphic and according to the ethnic group studied, it has been found to have
the capacity to confer susceptibility or resistance to NPC. Our aim was to review the most important described genetic associations
of HLA class I in NPC and to comment on the inconsistent associations found in the different NPC incidence areas. We believe
that the mechanisms of these associations may involve HLA genes through the differential capacity of each allele to present
antigens. However, because HLA genes contain various linked candidate genes, HLA-NPC associations should be carefully interpreted. |
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