Transglutaminase participates in the blockade of neurotransmitter release by tetanus toxin: evidence for a novel biological function |
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Authors: | Facchiano Francesco Deloye Florence Doussau Frédéric Innamorati Giulio Ashton Anthony C. Dolly J. Oliver Beninati Simone Facchiano Angelo Luini Alberto Poulain Bernard Benfenati Fabio |
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Affiliation: | (1) Department of Biology, University “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, Italy; |
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Abstract: | The aim of this study was to collect evidences on the role of transglutaminase (TG, E.C.2.3.2.13) in the antineoplastic properties exerted by nimesulide (NMS), a non-steroidal anti-inflammatory drug, on murine B16-F10 melanoma cells. Treatment of melanoma cells with nimesulide produces a considerable reduction of cell proliferation, paralleled by a remarkable decrease of the intracellular concentration of polyamines spermidine and spermine. NMS treatment induces cancer cell differentiation, likely through the observed enhancement of TG and tyrosinase activities and increase of melanin production, well known markers of melanocyte differentiation. The overall results highlight the possibility that nimesulide acts as antineoplastic agent likely through the induction of intracellular TG activity. |
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