Stepwise functionalization of ribonucleopeptides: optimization of the response of fluorescent ribonucleopeptide sensors for ATP |
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Authors: | Hasegawa Tetsuya Hagihara Masaki Fukuda Masatora Morii Takashi |
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Institution: | Institute of Advanced Energy, Kyoto University, Uji, Kyoto, Japan. |
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Abstract: | A stable complex of a peptide and RNA, ribonucleopeptide (RNP), provides a new framework to construct a macromolecular receptor for small molecules. The RNP receptor functionalized by a fluorophore-labeled Rev peptide exerts an optical signal associated with the ligand binding events. Replacing the Rev peptide of the ATP-binding RNP with a fluorophore-modified Rev peptide affords a fluorescent ATP sensor. |
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