| 胆红素对慢性阻塞性肺疾病大鼠血小板源性生长因子和胰岛素样生长因子表达的影响 |
| |
| 引用本文： | 高晓玲,郝丽婷,李建强,刘卓拉.胆红素对慢性阻塞性肺疾病大鼠血小板源性生长因子和胰岛素样生长因子表达的影响[J].中国组织化学与细胞化学杂志,2009,18(2):225-230. |
| |
| 作者姓名： | 高晓玲 郝丽婷 李建强 刘卓拉 |
| |
| 作者单位： | 山西医科大学第二医院呼吸科,太原,030001 |
| |
| 基金项目： | 山西省卫生厅科技攻关项目 |
| |
| 摘 要： | 目的探讨胆红素对慢性阻塞性肺疾病（COPD）大鼠肺组织血小板源性生长因子（PDGF-B）和胰岛素样生长因子（IGF-I）表达的影响。方法30只健康清洁级雄性Wistar大鼠（200-250g）,随机分为正常对照组、COPD模型组、胆红素干预组。观察肺组织病理形态,采用免疫组织化学染色检测肺组织中PDGF-B和IGF-I的表达。结果（1）肺病理组织学结果显示胆红素干预组肺病变局限且程度减轻;（2）COPD模型组PDGF-B（1.58±0.72）和IGF-I含量（2.23±0.63）与正常对照组（0.65±0.35,1.34±0.65）比较显著升高（均P〈0.05）;（3）胆红素干预组PDGF-B（1.20±0.56）和IGF-I含量（1.64±0.56）比模型组明显减低（均P〈0.05）,但与正常对照组比较仍较高（均P〈0.05）。结论PDGF-B和IGF-I在COPD显著增加,胆红素可以抑制PDGF-B和IGF-I的表达,可能是其对抗COPD的作用机制之一。
|
| 关 键 词： | 胆红素 慢性阻塞性肺疾病 血小板源性生长因子 胰岛素样生长因子 |
INFLUENCE OF BILIRUBIN ON THE EXPRESSIONS OF PDGF-B AND IGF-I IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| |
| Gao Xiaoling,Hao Liting,Li Jianqiang,Liu Zhuola.INFLUENCE OF BILIRUBIN ON THE EXPRESSIONS OF PDGF-B AND IGF-I IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE[J].Chinese Journal of Histochemistry and Cytochemistry,2009,18(2):225-230. |
| |
| Authors: | Gao Xiaoling Hao Liting Li Jianqiang Liu Zhuola |
| |
| Institution: | Department of Respiratory Disease;The Second Hospital of Shanxi Medical College;Taiyuan 030001;China |
| |
| Abstract: | Objective To investigate the effects of bilirubin on the chronic obstructive pulmonary disease(COPD) and the influence of bilirubin on the expressions of PDGF-B and IGF-I in pulmonary tissues of COPD.Methods Thirty male Wistar rats,200-250g in body weight,were randomly divided into 3 experimental groups: a control group,a COPD model group and a bilirubin pretreatment group(n = 10 each).Lung specimens were examined by histopathological technique.Immunohistochemistry was used to semiquantitatively analyse the... |
| |
| Keywords: | Bilirubin Chronic obstructive pulmonary disease(COPD) Platelet derived growth factor-B(PDGF-B) Insulin-like growth factor-I(IGF-I) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
