| 纳米磁性粒子在DNA分离与纯化中的应用进展 |
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| 引用本文： | 孙敏莉, 张皓,. 纳米磁性粒子在DNA分离与纯化中的应用进展[J]. 生物工程学报, 2001, 17(6): 601-603 |
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| 作者姓名： | 孙敏莉 张皓 |
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| 作者单位： | 上海第二医科大学附属仁济医院血管外科, |
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| 基金项目： | 上海市科委重点基础项目资助(99JC14016). |
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| 摘 要： | 纳米磁性粒子是一种新型的亲和纯析固相载体 ,其粒径小 ,具有超顺磁性 ,表面积大 ,表面可赋予多种反应基团如链霉亲和素、抗体等 ,或DNA片段 ,在磁场作用下可分离目的DNA ,已逐步应用于分子生物学领域中 ,有着极为广泛的应用前景。
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| 关 键 词： | 纳米磁性粒子 DNA分离与纯化 DNA三螺旋结构 |
| 文章编号： | 1000-3061(2001)06-0601-03 |
| 修稿时间： | 2001-05-25 |
The Development of Nanoparticles on DNA Isolation and Purification |
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| SUN Min|Li ZHANG Hao. The Development of Nanoparticles on DNA Isolation and Purification[J]. Chinese journal of biotechnology, 2001, 17(6): 601-603 |
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| Authors: | SUN Min|Li ZHANG Hao |
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| Affiliation: | Department of Vascular Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China. sml21@263.net |
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| Abstract: | Magnetic nanoparticle is a new solid|support of affinity chromatography. The particle size is small and it has superparamagnetism. It has large surface area and it can be endowed many reaction groups such as streptavidin, antibody or DNA fragments. The target DNA can be separated in magnetic field. The magnetic nanoparticle is applied in the biomolecular field gradually and it has a very broad prospect of appliance. |
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| Keywords: | magnetic nanoparticle DNA isolation and purification DNA triplex structure |
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