dabPNA: design, synthesis, and DNA binding studies |
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Authors: | Roviello Giovanni N Musumeci Domenica Moccia Maria Castiglione Mariangela Sapio Roberto Valente Margherita Bucci Enrico M Perretta Giuseppe Pedone Carlo |
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Affiliation: | Istituto di Biostutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy. giroviel@unina.it |
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Abstract: | In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an isomer of the aminoethylglycyl PNA (aegPNA) unit and the acyclic modification of the aminoprolyl PNA (ampPNA) monomer. In this work we present the solid phase synthesis of a dabPNA oligomer and of two aegPNAs containing a single dabPNA unit. A study relative to their binding ability towards DNA is also reported even in comparison with the well known aegPNAs. |
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