Synthesis and biological activities of substance P iodinated derivatives |
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Authors: | R Michelot H Gozlan J C Beaujouan M J Besson Y Torrens J Glowinski |
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Affiliation: | 1. Institut de Chimie des Substances Naturelles, CNRS 91190 Gif sur Yvette, France;2. INSERM U. 114, Collège de France 11, place Marcelin Berthelot, 75231 Paris cedex 5, France |
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Abstract: | The synthesis of four substance P (SP) derivatives obtained by coupling the monoiodo and diiodo Bolton and Hunter reagents with synthetic SP is described. These compounds were proved to be good ligands for SP antibodies. As seen for SP, they exhibit a high biological activity in the guinea pig ileum bioassay. |
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