Digitalis-induced cell stimulation : Support for a two-receptor model |
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| Authors: | Lennart Hammarstr m,C. I. Edvard Smith |
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| Affiliation: | Department of Immunobiology, Wallenberg Laboratory, Lilla Frescati, S-104 05 Stockholm 50, Sweden |
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| Abstract: | Digitalis glycosides are potent polyclonal B cell activators in digitalis-resistant species. The stimulatory capacity is not mediated via their interaction with Na+, K+ ATPase (EC 3.6.1.3) but is due to binding to a distinct mitogen receptor located in the cell membrane. Potassium was found to influence the dose-response profile of digitalis-induced mitogenesis, thus suggesting a physiological relationship between the stimulating receptor on lymphoid cells and the Na+, K+ ATPase. |
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| Keywords: | To whom offprint requests should be directed. |
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