DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation. |
| |
| Authors: | C E Ibanez A Garcia U Stober-Grsser and J S Lipsick |
| |
| Institution: | Department of Pathology, University of California, San Diego, La Jolla 92093-0612. |
| |
| Abstract: | The product of the v-myb oncogene of avian myeloblastosis virus is a nuclear protein with an associated DNA-binding activity. We demonstrated that the highly conserved amino-terminal domain of p48v-myb is required for its associated DNA-binding activity. This activity is not required for the nuclear localization of p48v-myb. Furthermore, the associated DNA-binding activity and nuclear localization of p48v-myb together are not sufficient for transformation. |
| |
| Keywords: | |
|
|
