陕西省汉族人群11号染色体10个STR基因座的遗传多态性研究

为了分析陕西汉族人群中11号染色体上10个短串联重复序列(short tandem repeat, STR)基因座的多态性，采用荧光标记基因扫描方法，对11号染色体上的D11S1760、D11S4102、D11S4116、D11S4207、D11S4162、D11S914、D11S4127、D11S917、D11S4146和^D11S915基因座的遗传多态性进行分析。结果显示：D11S1760、D11S4102、D11S4116、D11S4207、D11S4162、D11S914、D11S4127、D11S917、D11S4146和D11S915基因座分别检出17、11、15、11、4、6、7、12、11和13个等位基因，41、18、36、30、8、10、16、30、29和32个基因型，等位基因型符合Hardy-Weinberg平衡（P>0.05）。其杂合度分别为86.72%、67.95%、83.90%、85.96%、58.18%、57.63%、72.60%、72.73%、77.87%和86.40%，表明11号染色体上的这10个STR基因座在汉族人群中有较好的多态性，是理想的遗传标记物。

Analysis of genetic polymorphisms of 10 STR loci on chromosome 11 in a Shaanxi Han population

D11S1760,D11S4102,D11S4116,D11S4207,D11S4162,D11S914,D11S4127,D11S917,D11S4146 and D11S915 of 10 short tandem repeat(STR) loci on chromosome 11 were analyzed by fluorescence-based gene scan tech-nique to understand the genetic polymorphisms of those STR loci on chromosome 11 in a Han population in Shaanxi pro-vince.The results showed that the number of alleles and genotypes observed at loci D11S1760,D11S4102,D11S4116,D11S4207,D11S4162,D11S914,D11S4127,D11S917,D11S4146 and D11S915 were 17,11,15,11,4,6,7,12,11 and 13 for alleles and 41,18,36,30,8,10,16,30,29 and 32 for genotypes,respectively.All the 10 loci were in Hardy-Weinberg equilibrium.The heterozygosities of each STR locus was 86.72%,67.95%,83.90%,85.96%,58.18%,57.63%,72.60%,72.73%,77.87% and 86.40%.It concluded the 10 loci on chromosome 11 were relatively highly genetic polymorphic in Han populations and could provide useful markers for genetic studies.