Triterpenes and neolignans from the roots of Nannoglottis carpesioides |
| |
Authors: | Xue Cai-Bin Chai Duo-Wu Jin Xiao-Jie Bi Yu-Rong Yao Xiao-Jun Wu Wang-Suo Zhu Ying |
| |
Institution: | State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. |
| |
Abstract: | Seven oleanane-type triterpenes and two 8-O-4′-neolignans, along with five known compounds (three 28-noroleanane-type triterpenes, one sarratane triterpene, and one neolignan), were isolated from roots of Nannoglottis carpesioides. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, HRMS, and CD. The absolute configurations of two triterpenes were determined by experimental and calculated circular dichroism (CD) and optical rotation values. Ten compounds were evaluated for their cytotoxicity against human promyelocytic leukaemia (HL-60) and human hepatoma (Hep-G2) cells using the MTT assay. The antioxidant activities of these compounds were assessed by ABTS radical-scavenging assays. Among the tested compounds, three compounds exhibited moderate radical-scavenging activity against ABTS +, with IC50 values of 22.4, 17.4, and 23.2 μM, respectively. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|