Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats |
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Authors: | Clementi G Caruso A Cutuli V M Prato A Mangano N G Amico-Roxas M |
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Affiliation: | Institute of Pharmacology, University of Catania, School of Medicine, Italy. |
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Abstract: | The antiinflammatory effect of ADM was studied in different models of inflammation and compared to the one of CGRP. Peptides were active against acetic acid-induced peritonitis in the rats. ADM and CGRP exerted the antiinflammatory effect at different doses, 400 and 20 ng/kg respectively, but with different efficacy (ADM >CGRP). This effect was blocked by pretreatment with CGRP (8-37) fragment or with L-NAME. No antiinflammatory activity was evidenced against serotonin- or carrageenin-induced rat paw edema. Our data suggest that ADM exerts antiinflammatory activity in the model characterized by a vascular component. This effect involves CGRP receptors and appears to be mediated by nitric oxide system. |
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