Department of Chemistry Research, Bayer Research Center, West Haven, CT 06516, USA. jacques.dumas.b@bayer.com
Abstract:
The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class.