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Discovery of a new class of p38 kinase inhibitors |
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| Authors: | Dumas J Sibley R Riedl B Monahan M K Lee W Lowinger T B Redman A M Johnson J S Kingery-Wood J Scott W J Smith R A Bobko M Schoenleber R Ranges G E Housley T J Bhargava A Wilhelm S M Shrikhande A |
| Institution: | Department of Chemistry Research, Bayer Research Center, West Haven, CT 06516, USA. jacques.dumas.b@bayer.com |
| Abstract: | The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class. |
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