蛋白的高尔基体定位

高尔基体既是蛋白质修饰、分选、水解加工的场所，又是分泌物质的转运站，每时每刻都有大量的蛋白进出高尔基体。在这种情况下，高尔基体仍能保持完整且高度有序的结构，表明高尔基体驻留蛋白有精确的定位信号，以保证它们定位于正确的区隔，而不会沿着分泌途径被运输出去。高尔基体内有几种不同类别的膜蛋白，包括糖基转移酶、周缘膜蛋白、病毒蛋白和受体等。研究显示，有多种定位信号和定位机制参与了蛋白的高尔基体定位。

Localization of Proteins to the Golgi Apparatus

The Golgi apparatus plays a major role in the modification of newly synthesized proteins and also serve as a major sorting point in the secretory pathway. It maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept along the secretory pathway. There are a number of distinct groups of Golgi membrane proteins, including glycosyltransferases, peripheral membrane proteins, receptors and viral proteins. Studies indicate that there are a number of different Golgi localization signals and mechanisms for retaining proteins to the Golgi apparatus.