High-throughput and ultra-high-throughput screening: solution- and cell-based approaches |
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Authors: | Sundberg S A |
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Institution: | Caliper Technologies Corporation, CA 94043, USA. steve. sundberg@calipertech.com |
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Abstract: | The trend towards assay miniaturization for high-throughput and ultra-high-throughput screening continues to spur development of homogeneous, fluorescence-based assays in higher density, smaller volume microplate formats. Recently, first-generation microfluidic devices have been designed for performing continuous-flow biochemical and cell-based assays. These devices provide orders-of-magnitude reduction in reagent consumption, and offer the potential for implementing high-throughput screening in formats that integrate up-front compound handling with unique assay functionality. |
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