Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy |
| |
| Authors: | Renette Thomas Librizzi Damiano Endres Thomas Merkel Olivia Beck-Broichsitter Moritz Bege Nadja Petersen Holger Curdy Catherine Kissel Thomas |
| |
| Affiliation: | Department of Pharmaceutics and Biopharmacy, Philipps-Universit?t Marburg, Marburg, Germany. |
| |
| Abstract: | The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel-loaded nanoparticles with high loading efficiency and narrow-size distribution is successful. For non-invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti-tumor efficiency compared to the standard Taxol?, which is reflected in a significantly slower tumor growth compared to the NaCl control group. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
