The role of cell interactions in the control of lymphocyte traffic.

The effect of pretreatment of ⁵¹Cr-labelled lymph node cells with neuraminidase, trypsin, phospholipase A, Con A and LPS on their fate in intact and splenectomized recipients following intravenous injections was studied. Decreased lymph node entry was observed in all experimental groups in which intact mice were used as recipients. Evidence for this decrease to be the result of a change in the interaction of the circulating cells with the cells in the liver, lungs or spleen and not the result of a specific defect of the interaction between the lympocytes and the post-capillary venule endothelium is presented and discussed.