Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein |
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| Authors: | Alice Y Pollitt Robert H Insall |
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| Institution: | (1) School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK;(2) Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK;(3) School of Medicine, University of Birmingham, Birmingham, B15 2TT, UK |
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| Abstract: | Background SCAR/WAVE proteins couple signalling to actin polymerization, and are thus fundamental to the formation of pseudopods and
lamellipods. They are controlled as part of a five-membered complex that includes the tiny HSPC300 protein. It is not known
why SCAR/WAVE is found in such a large assembly, but in Dictyostelium the four larger subunits have different, clearly delineated functions. |
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