Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision |
| |
Authors: | Leamey Catherine A Merlin Sam Lattouf Paul Sawatari Atomu Zhou Xiaohong Demel Natasha Glendining Kelly A Oohashi Toshitaka Sur Mriganka Fässler Reinhard |
| |
Institution: | 1 Department of Physiology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, Australia, 2 Brain and Cognitive Sciences and Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Molecular Medicine, Max-Planck Institute for Biochemistry, Martinsried, Germany |
| |
Abstract: | Binocular vision requires an exquisite matching of projections from each eye to form a cohesive representation of the visual world. Eye-specific inputs are anatomically segregated, but in register in the visual thalamus, and overlap within the binocular region of primary visual cortex. Here, we show that the transmembrane protein Ten_m3 regulates the alignment of ipsilateral and contralateral projections. It is expressed in a gradient in the developing visual pathway, which is consistently highest in regions that represent dorsal visual field. Mice that lack Ten_m3 show profound abnormalities in mapping of ipsilateral, but not contralateral, projections, and exhibit pronounced deficits when performing visually mediated behavioural tasks. It is likely that the functional deficits arise from the interocular mismatch, because they are reversed by acute monocular inactivation. We conclude that Ten_m3 plays a key regulatory role in the development of aligned binocular maps, which are required for normal vision. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
| 点击此处可从《PLoS Biology》浏览原始摘要信息 |
| 点击此处可从《PLoS Biology》下载免费的PDF全文 |
|