Micro-emultocrit technique: A valuable tool for determination of critical HLB value of emulsions |
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| Authors: | Janus P F Macedo Leonardo L Fernandes Fábio R Formiga Michael F Reis Toshiyuiky Nagashima Júnior Luiz A L Soares E Socrates T Egito |
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| Institution: | Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450 Natal-RN, Brazil |
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| Abstract: | The aim of this work was to develop a methodology for rapid determination of the critical hydrophilic-lipophilic balance (HLB)
value of lipophilic fractions of emulsions. The emulsions were prepared by the spontaneous emulsification process with HLB
value from 4.3 to 16.7. The preparations were stored at 2 different temperatures (25°C and 4°C) and their physicochemical
behavior was evaluated by the micro-emultocrit technique and the long-term stability study. The experimental data show a reverse
relationship between HLB values of the surfactant mixtures and emulsion stability. A close correlation between the results
for both stability procedures was observed, suggesting the use of micro-emultocrit to predict stabilities of such systems.
In addition, it was found that the critical HLB of the Mygliol 812 was 15.367.
Published: March 10, 2006 |
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| Keywords: | emulsions hydrophilic-lipophilic balance spontaneous emulsification process micro-emultocrit creaming index stability |
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