Mathematical models of cell cycle regulation |
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Authors: | Fuss Hendrik Dubitzky Werner Downes C Stephen Kurth Mary Jo |
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Affiliation: | School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, UK. fuss-h@ulster.ac.uk |
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Abstract: | The cell division cycle is a fundamental process of cell biology and a detailed understanding of its function, regulation and other underlying mechanisms is critical to many applications in biotechnology and medicine. Since a comprehensive analysis of the molecular mechanisms involved is too complex to be performed intuitively, mathematical and computational modelling techniques are essential. This paper is a review and analysis of recent approaches attempting to model cell cycle regulation by means of protein-protein interaction networks. |
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Keywords: | cell cycle, computer simulation, systems biology, protein protein interaction, regulatory networks |
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