The linkage information content value of polymorphism genetic markers in model-free linkage analysis |
| |
| Authors: | Guo Xiuqing Olson Jane M Elston Robert C Niu Tianhua |
| |
| Affiliation: | Division of Medical Genetics, Department of Medicine and Pediatrics, Spielberg Pediatrics Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048, USA. Xiuqing.Guo@cshs.org |
| |
| Abstract: | Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, we give corrected LIC values for full sib, grandparent-grandchild, first cousin and avuncular pairs, and indicate the availability of a computer program to calculate them. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
