Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock |
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| Authors: | Lamin Tayar Kyoko Higo Yoshinao Kubo Yun Wang Ling-Min Lu Fengmin Zhang Yasumasa Iwatani Ling Wang Takeshi Ono Michiyuki Maeda Hiroyuki Sakai Akinori Ishimoto |
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| Affiliation: | Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research,1. Department of Pathology and Biology of Diseases, Graduate School of Medicine,3. and Institute for Frontier Medical Science,4. Kyoto University, Sakyo-ku, Kyoto 606-8507, and Department of Pathology, School of Medicine, Fujita Health University, Toyoake 470-1192,2. Japan |
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| Abstract: | The pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and ecotropic helper virus (BM5eco) isolated from the complex to BALB/c nude mice were studied to elucidate the possible role of replication-competent helper virus in inducing the monoclonal outgrowth of lymphoid cells. Neither LP-BM5 nor BM5eco was pathogenic in adult BALB/c nude mice. However, B-cell lymphoma developed with a very high frequency when either virus was inoculated into newborn BALB/c nude (nu/nu) mice. The cells from the B-cell lymphoma were easily transplanted into nude mice. These results suggested that ecotropic helper virus in the MAIDS virus complex plays an important role in inducing the monoclonal outgrowth of lymphoid cells under immunodeficient conditions caused by defective virus. |
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