Study of the restitution of action potential duration using the artificial neural network |
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Authors: | Han Xinwei Chen Yao Gao Weihua Xue Juel Han Xiaodong Fang Zuxiang Yang Cuiwei Wu Xiaomei |
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Affiliation: | Biomedical Engineering Institute, Huazhong University of Science and Technology, China. |
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Abstract: | It is widely accepted that the APD (action potential duration) restitution plays a key role in the initializing and maintaining of the reentry arrhythmias. The Luo-Rudy II models paced with different protocols showed that the current APD had a complex relation with the previous APDs and diastole intervals (DIs). This relation could not be accurately described by a single exponential function. We used an artificial neural network to formularize this relation. The results suggested that back-propagation (BP) network could predict the current APD from the information of the first three previous beats. This would help provide a target for potential anti-arrhythmic therapies. |
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Keywords: | Luo-Rudy II model Action potential duration (APD) APD restitution Artificial neural network |
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