Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology |
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| Authors: | Wright W E Shay J W |
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| Affiliation: | Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA. |
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| Abstract: | Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer. |
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