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Transdominant regulation of integrin function: Mechanisms of crosstalk |
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| Authors: | Annette M Gonzalez Ramona Bhattacharya Gregory W deHart Jonathan CR Jones |
| Institution: | 1. Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany;2. Euroimmun AG, Lübeck, Germany;3. Department of Neurology, University of Lübeck, Lübeck, Germany;4. Institute of Clinical Chemistry, Neuroimmunology Unit, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany;1. Molecular Biology, Cell Biology & Biochemistry Program, Boston University, Boston, MA 02215, United States;2. Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, United States;3. Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States;4. Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, United States |
| Abstract: | Transdominant inhibition of integrins or integrin–integrin crosstalk is an important regulator of integrin ligand binding and subsequent signaling events that control a variety of cell functions in many tissues. Here we discuss examples of integrin crosstalk and detail our current understanding of the molecular mechanisms that are involved in this receptor phenomenon. The cytoskeleton associated protein talin is a key regulator of integrin crosstalk. We describe how the interaction of talin and the cytoplasmic tail of β integrin is controlled and how competitive inhibitors of this binding play a role in integrin crosstalk. We conclude with a discussion of how integrin crosstalk impacts the interpretation of integrin inhibitor and knockdown studies in both the laboratory and clinical setting. |
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