Controlling of bone morphogenetic protein signaling |
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| Authors: | Shan Zeng Jia Chen Hong Shen |
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| Affiliation: | 1. Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China;2. Medical Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China;1. Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Canada;2. Advanced Education in General Dentistry, Prince Abdulrahman Advanced Dental Institute, Kingdom of Saudi Arabia, Saudi Arabia;1. Chair of Vascular and Internal Diseases, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland;2. Clinic of Vascular and Internal Diseases, Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland;3. Department of Psychiatric Nursing, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland;2. Department of Radiology, University Hospitals Case Medical Center, Cleveland, OH;3. Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH;4. Department of Nuclear Medicine, Cleveland Clinic, Imaging Institute, Cleveland, OH;5. Institute of Diagnostic and Interventional Radiology, University Hospitals, Düsseldorf, Germany;1. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. Immunopharmacology Laboratory, Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan;4. AM/PM Veterinary Hospital, 4872 Olinda St., Yorba Linda, CA 92886, United States;5. State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, PR China;1. The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA;2. The Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil;3. The Department of Cutaneous Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA;1. Mid-Atlantic Permanente Medical Group, 2101 East Jefferson Street, Rockville, MD 20852, USA;2. Department of Radiology, Boston Children''s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA;3. Department of Radiology and Pediatric Pulmonology, Sophia Children''s Hospital, Erasmus Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands;4. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA;5. Magnetic Resonance, Research and Development, Siemens Healthcare, 1620 Tremont St., Boston, MA 02120, USA |
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| Abstract: | Bone morphogenetic proteins (BMPs) are multifunctional growth factors and play crucial roles during embryonic development, skeletal development, and cell fate determination. Their signals are transduced from cell membrane to the nucleus through intracellular signaling mediators. At present, different signaling pathways have been identified, and elaborate of network of regulators involved in the signaling control. The aim of the present review is to describe the recent understanding of BMPs signaling with emphasis on the regulation of its signal transduction at extracellular level, intracellular level, Smad-interacting factors in the nucleus, and Smad-independent signaling pathways, respectively. |
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