Oxinobactin, a siderophore analogue to enterobactin involving 8-hydroxyquinoline subunits: synthesis and iron binding ability |
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| Authors: | d'Hardemare Amaury du Moulinet Alnaga Nivine Serratrice Guy Pierre Jean-Louis |
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| Affiliation: | Département de Chimie Moléculaire (UMR 5250), Université Joseph Fourier-Grenoble, 301 rue de la Chimie, BP 53X, 38041 Grenoble cedex 9, France. amaury.d-hardemare@ujf-grenoble.fr |
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| Abstract: | Oxinobactin, a siderophore analogue to enterobactin but possessing 8-hydroxyquinoline instead of catechol complexing subunits, has been synthesized starting from L-serine and 8-hydroxyquinoline. Comparative iron binding studies showed that oxinobactin is as effective as enterobactin for the complexation of Fe(III) at physiological pH but with improved complexing ability at acidic pH. |
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