| GPX－abzyme对受XO／HX系统损伤的心肌线粒体的保护作用 |
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| 引用本文： | 邢辉,李健学,冯雁,孙旭东,杨同书. GPX－abzyme对受XO／HX系统损伤的心肌线粒体的保护作用[J]. 中国生物化学与分子生物学报, 1996, 12(4): 450-454 |
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| 作者姓名： | 邢辉 李健学 冯雁 孙旭东 杨同书 |
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| 作者单位： | 中国预防医学科学院环境卫生与卫生工程研究所，吉林大学酶工程国家重点实验室，北京北方生物技术研究所 |
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| 摘 要： | 探讨了研制的具有谷胱甘肽过氧化物酶活力的含硒抗体酶（ＧＰＸ－ａｂｚｙｍｅ）对于受损心肌线粒体的保护作用，利用牛的心肌线粒体为实验材料，通过线粒体的膨胀度、脂质过氧化物含量、ＣＣＯ活力变化及电镜观察等几个方面证明ＧＰＸ－ａｂｚｙｍｅ能抵抗ＸＯ／ＨＸ系统产生的自由基的损伤作用，ＥＳＲ研究也表明ＧＰＸ－ａｂｚｙｍｅ能明显降低ＸＯ／ＨＸ损伤系统中的自由基含量。
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| 关 键 词： | 抗体酶 抗氧化损伤 心肌线粒体 |
| 收稿时间： | 1996-08-20 |
Protection of Glutathione Peroxidase-abzyme on Myocardial Mitochondria in XO/HX Injuring System |
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| Xing Hui,Li Jian-Xue. Protection of Glutathione Peroxidase-abzyme on Myocardial Mitochondria in XO/HX Injuring System[J]. Chinese Journal of Biochemistry and Molecular Biology, 1996, 12(4): 450-454 |
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| Authors: | Xing Hui Li Jian-Xue |
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| Affiliation: | (Institute of Environmental Health &.Engineering,Chinese Academy of Preventive Medicine.Beijing 100050)(Laboratory of Enzyme Engineering,Jilin University,Changchun 130023 |
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| Abstract: | GPX-abzyme was prepared and its protective function to the injured myocardial mitrochondia was investigated. Using the bovine myocardial mitochondria as experimental material,the results showed that the GPX-abzyme may inhibit free radical injuries by the XO/HX system studying the swelling of mitochondia,quantity of lipid peroxide production,changes of CCO activity and the transmission electron microscopic observation.Studies of the ESR changes indicated that GPX-abzyme could obviously decrease the amount of free radical in the XO/HX injuring system. |
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| Keywords: | Abzyme Antioxidantion Myocardial mitochondria |
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