Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer |
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| Authors: | Yaren Arzu Turgut Sebahat Ayada Ceylan Akcilar Raziye Degirmencioglu Serkan Gokoz Dogu Gamze |
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| Affiliation: | Pamukkale University, Medical Faculty, Department of Medical Oncology, Denizli, Turkey. arzu_yaren@yahoo.com |
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| Abstract: | We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p=0.04), with low histological grade (p=0.04), with positive hormone receptor status (p=0.01), and in patients without recurrence (p=0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. |
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| Keywords: | BRCA, BReast CAncer CA, cytosine-adenine CI, confidence interval DFS, disease-free survival DNA, deoxyribonucleic acid dNTP, deoxynucleoside triphosphates ER, estrogen receptor IGF, ?nsulin-like growth factor IGFBP, ?nsulin-like growth factor binding protein IGFR, ?nsulin-like growth factor receptor ORs, odds ratios OS, overall survival PCR, polymerase chain reaction PR, progesterone receptor UV, ultraviolet VEGF, vascular endothelial growth factor |
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