Determination of pyridoxal phosphate levels in the brains of audiogenic and normal mice |
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| Authors: | Shin-Ho Chung Robert A. Cox |
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| Affiliation: | (1) National Institute for Medical Research, Mill Hill, NW7 1AA London |
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| Abstract: | The concentrations of pyridoxal-5 -phosphate in the brains of audiogenic and normal mice were measured fluorimetrically. The brain of the audiogenic mouse (DBA/2J) contains 25% more pyridoxal-5-phosphate than the brain of a control mouse. Intraperitoneal injection of this substance causes a transient increase of its concentration in the brain, lasting a few hours. The substance thereafter is degraded to pyridoxal and pyridoxic acid. |
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