大肠癌患者血清和组织中sIL-2R 和sICAM-1 水平的变化及意义

目的：探讨可溶性白细胞介素2 受体（sIL-2R）和可溶性细胞间粘附分子1（sICAM-1）的水平在大肠癌患者血清和组织中的变化及临床意义。方法：选择本院于2010 年1月-2012 年12 月收治的55例大肠癌患者作为观察组，选取同期收治的41 例大肠息肉患者作为对照组，38例健康志愿者作为健康组，应用双抗体夹心ELISA法对上述三组血清和组织中的sIL-2R 和sICAM-1水平进行检测，对比分析上述指标的变化情况及其临床意义。结果：观察组血清和组织中sIL-2R 水平分别为（210.3 ± 128.5）pmol/L、（235.8 ± 172.4）pmol/L，明显高于对照组与健康组，比较差异均有统计学意义（P<0.05），且sICAM-1 平均水平为（392.4±133.3）p/ug/L，显著高于对照组和健康组，比较差异亦有统计学意义（P<0.05）；观察组术后sIL-2R和sICAM-1 水平分别为（85.1±41.7）pmol/L、287.3 ± 106.1（p/ug/L），均显著低于术前，比较差异有统计学意义（P<0.05）。结论：大肠癌患者机体中sIL-2R 及sICAM-1 的水平与疾病的发生和存在有密不可分的关系，故临床中，测定两指标的含量对大肠癌的诊断有一定的临床意义，可将其作为一个较为客观的指标进行检测。

Changes and Significance of Serumand Tissue of Patientswith Colorectal Cancer in sIL-2R and sICAM-1 Levels

Objective:To investigate the levels of soluble interleukin-2 receptor (sIL-2R) and soluble intercellular adhesionmolecule-1 (sICAM-1) and its clinical significance in patients with colorectal cancer in serum and tissue.Methods:Selected 55 patientswith colorectal cancer in my hospital from2010 January to 2012 Decemberas the observation group,41 cases of colorectal polyps patientsas a control group, 38 healthy volunteers as health group, double antibody sandwich ELISA for serum and tissues of the three groupsdetection of sIL-2R and sICAM-1 levels,comparative analysis and clinical significance of changes in these indicators.Results:The serumand tissues sIL-2R levels were (210.3 ± 128.5) pmol/L, (235.8 ± 172.4) pmol/L, significantly higher than the healthy group, thedifference was statistically significant(P<0.05), and the average level of sICAM-1 (392.4 ± 133.3)p/ug/L, significantly higher than healthygroup, there were significant differences(P<0.05); observation group after sIL- 2R and sICAM-1 levels were (85.1 ± 41.7) pmol/L, 287.3± 106.1 (p/ug/L),were significantly lower than before the surgery , the difference was statistically significant (P<0.05).Conclusion:Thebody of patients with colorectal cancer occurred in sIL-2R and sICAM-1 levels with disease and there is a close relationship, so clinical,diagnostic determination of the two indicators for colorectal cancer has clinical significance, can be as a more objective indicator fortesting.