| 间隙连接及其调控因素 |
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| 引用本文： | 杨德鸿,高天明,陈建庭,金大地.间隙连接及其调控因素[J].生物化学与生物物理进展,2001,28(4):463-466. |
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| 作者姓名： | 杨德鸿 高天明 陈建庭 金大地 |
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| 作者单位： | 1. 第一军医大学南方医院,
2. 第一军医大学基础部生理教研室, |
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| 摘 要： | 概述了间隙连接的结构和功能,以及pH值、电压、生长因子对它的调节作用.间隙连接作为相邻细胞间信息物质通道,起着传递细胞信息,协调细胞群体功能的作用,但是其形成过程以及对机体生理功能影响的研究有待进一步深入.pH值降低可引起间隙连接通道的关闭,电压升高降低通道的导电性,生长因子可通过影响间隙连接蛋白的形成和降解、促使间隙连接蛋白磷酸化调节其通透性.
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| 关 键 词： | 间隙连接 pH值 电压 生长因子 |
| 收稿时间： | 2000/7/21 0:00:00 |
| 修稿时间： | 2000年7月21日 |
Gap Junction: Modulated by pHi, Voltage and Cytokines |
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| YANG De-Hong,GAO Tian-Ming,CHEN Jian-Ting and JIN Da-Di.Gap Junction: Modulated by pHi, Voltage and Cytokines[J].Progress In Biochemistry and Biophysics,2001,28(4):463-466. |
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| Authors: | YANG De-Hong GAO Tian-Ming CHEN Jian-Ting and JIN Da-Di |
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| Institution: | The Spinal and Orthopedic Department, Nanfang Hospital, The First Military Medical University, Guangzhou 510515,China;Department of Physiology, The First Military Medical University, Guangzhou 510515, China;The Spinal and Orthopedic Department, Nanfang Hospital, The First Military Medical University, Guangzhou 510515,China;The Spinal and Orthopedic Department, Nanfang Hospital, The First Military Medical University, Guangzhou 510515,China |
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| Abstract: | s Structure and function of gap junction as well as the role of pH i, voltage and cytokines on the modulating of gap junction are introduced. Gap junction is an information channel between the adjacent cells, with the function that delivering message and coordinating the actions of cell groups, but its formation and its function on the physical events need more research. The lower pH i closes the gap junctional channel and it is explained by "particle receptor" model. The increase of voltage downregulates the conductance of the channel. Cytokines regulate the permeability of gap junction by changing the synthesis and degradation of connexin, enhancing the phosphatizing the connexin. |
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| Keywords: | gap junctions pHi voltage cytokine |
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