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Gut flora enhance bacterial clearance in lung through toll-like receptors 4
Authors:Tzyy-Bin Tsay  Ming-Chieh Yang  Pei-Hsuan Chen  Ching-Mei Hsu  Lee-Wei Chen
Affiliation:(1) Department of Surgery, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan;(2) Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;(3) Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan;(4) Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan
Abstract:

Background  

The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia through TLR4 signaling.
Keywords:gut flora   pneumonia   lipopolysaccharide   Toll-like receptors   NF-κB
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